PHYSIOTHERAPEUTIC METHODS FOR CORRECTING OXIDATIVE STRESS Key words: oxidative stress, ozone therapy, hypercapnotherapy, intravenous laser blood irridation, extremely high frequency therapy, magnetic therapy, SCENAR-therapy. Oxidative stress is prooxidant – antioxidant disbalance and one of the major etiopathogenetic

Prooxidants are activated oxygen metabolites (AOM), active oxygen forms and free radicals of any etiology that activate free radical oxidation of all boimolecules, in particular lipids. In pathology the amount of prooxidants increases and free radical oxidation activation processes of all boimolecules, in particular lipids of biological membranes, go out of control. The accumulation of LPO products, especially final, may damage cell membranes, in particular their lipid bilayer [6, 19]. Lipid peroxidation products produce toxic effect due to biopolymer linking, mitochondrial swelling and division of oxidative phosphorylation, as well as inactivation of enzymes that are involved in breathing and glycolysis. They oxidate proteins, damage DNA, can slow down and even stop division and growth of cells, destabilize cell membranes [8, 34]. As a result, under the influence of lipid peroxidation stability and normal state of cell membranes change as their physicochemical properties microviscosity of the lipid bilayer and zones of protein-lipid contacts, flow properties, membrane potential, polarity of membrane inner side, membrane proteins modify, ionic permeability of lipid layer changes, its stability decreases change [9]. All these processes are accompanied by destabilization of cells, in particular erythrocytes, reduction of their deformability, reduction in life expectancy, increase of ectoglobular hemoglobin [7]. Peroxidation makes the cell go around in a vicious circle of bioenergy and homeostasis disorders, which destructs the cell, if not broken.